NucliSENS® easyMag®

Count the Ways

NucliSENS® easyMAG® is an IVD-labeled automated system for total nucleic acid extraction from a variety of sample types and volumes. 

The NucliSENS® easyMAG® is a breakthrough platform specifically optimized for total nucleic acid extraction from biological samples. The system automates an enhanced magnetic silica version of bioMérieux’s proprietary BOOM® technology, a gold standard for the universal extraction of RNA and DNA.

In addition, bioMérieux offers other NucliSENS® systems to meet molecular diagnostics testing needs:

  • NucliSENS® miniMAG® is a manual system for extraction of total nucleic acids in various specimens.
  • NucliSENS EasyQ® is the first automated system to combine NASBA technology and real-time molecular beacon detection.


For Clinical Laboratories:

  • Nucleic acid extraction in front of molecular infectious disease assays, molecular oncology assays, molecular genetics assays

For BioPharma:

  • Nucleic acid extraction


As the result of an exceptionally robust design, workflow is extremely flexible and the operation of the system is highly efficient. An intelligent design results in a vast reduction in plastic waste compared to other automated systems and maximizes productivity for your molecular laboratory. The system also incorporates thorough sample and reagent traceability as well as a number of safeguards that optimize system performance.



  • Run size: 1-24 samples per run
  • Nucleic acid binding to NucliSENS® magnetic silica particles
  • Sample types validated: plasma, serum, whole blood, CSF, urine, stool and respiratory samples
  • Input volume: from 10 to 1000 microliters
  • Output volume: from 25 to 110 microliters, selectable in 5 ul increments
  • Barcode reader traceability
  • Same reagents for all protocols
  • Hands-on time: <15 minutes for 24 samples
  • Turnaround time: between 40 and 60 minutes for 24 extractions (depending on workflow)

Workflow Flexibility:

  • Lysis on board
  • Lysis off board
  • Parallel processing of various sample types and volumes
  • Parallel processing of primary and pre-lysed samples
  • Selection of specific elution volumes for individual samples in the same run


  • Width: 1000 mm
  • Depth: 650 mm
  • Height: 530 mm
  • Weight: 125 kg



For Clinical Laboratories:

  • Nucleic acid extraction in front of molecular infectious disease assays, molecular oncology assays, molecular genetics assays

For BioPharma:

  • Nucleic acid extraction


NucliSENS® Nucleic Acid Extraction Reagents for easyMAG®:

  • EasyMAG® Magnetic Silica
  • EasyMAG® Disposables
  • EasyMAG® Lysis Buffer
  • EasyMAG® Wash Buffers 1, 2 and 3
  • Biohit Pipette Tips



Nicola Dundas, N. Kristine Leos, Midori Mitui, Paula Revell, and Beverly Barton Rogers. Comparison of Automated Nucleic Acid Extraction Methods with Manual Extraction. J. Mol. Diagn. 2008 10: 311-316; published online before print as doi:10.2353/jmoldx.2008.070149

Martró E, García-Sierra N, González V, Saludes V, Matas L, Ausina V. Evaluation of an automated nucleic acid extractor for hepatitis C viral load quantification. J Clin Microbiol. 2009 Jan 7.

Hindiyeh M, Smollen G, Grossman Z, Ram D, Davidson Y, Mileguir F, Vax M, Ben David D, Tal I, Rahav G, Shamiss A, Mendelson E, Keller N. Rapid detection of blaKPC carbapenemase genes by real-time PCR. J Clin Microbiol. 2008 Sep;46(9):2879-83. Epub 2008 Jul 9.

A. Petrich, J. Mahony, S. Chong, G. Broukhanski, F. Gharabaghi, G. Johnson, L. Louie, K. Luinstra, B. Willey, P. Akhaven, L. Chui, F. Jamieson, M. Louie, T. Mazzulli, R. Tellier, M. Smieja, W. Cai, M. Chernesky, S. E. Richardson, for the Ontario Laboratory Working Group for the Rapid Diagnosis of Emerging Infections. Multicenter Comparison of Nucleic Acid Extraction Methods for Detection of Severe Acute Respiratory Syndrome Coronavirus RNA in Stool Specimens. Received 28 November 2005/ Returned for modification 6 February 2006/ Accepted 24 April 2006

Koidl C, Bozic M, Hadzisejdic I, Grahovac M, Grahovac B, Kranewitter W, Marth E, Kessler HH. Comparison of molecular assays for detection and typing of human papillomavirus. Am J Obstet Gynecol. 2008 Aug;199(2):144.e1-6. Epub 2008 Apr 25.

Ginocchio CC, Manji R, Lotlikar M, Zhang F. Clinical evaluation of NucliSENS magnetic extraction and NucliSENS analyte-specific reagents for real-time detection of human metapneumovirus in pediatric respiratory specimens. J Clin Microbiol. 2008 Apr;46(4):1274-80. Epub 2008 Feb 13.

Stevens W, Horsfield P, Scott LE. Evaluation of the performance of the automated NucliSENS® easyMAG® and EasyQ® systems versus the Roche AmpliPrep-AMPLICOR combination for high-throughput monitoring of human immunodeficiency virus load. J Clin Microbiol. 2007 Apr;45(4):1244-9. Epub 2007 Jan 31.

Loens K, Bergs K, Ursi D, Goossens H, Ieven M. Evaluation of NucliSens® easyMAG® for automated nucleic acid extraction from various clinical specimens. J Clin Microbiol. 2007 Feb;45(2):421-5. Epub 2006 Dec 13.

Pioneering diagnostics