Real-Time PCR Solution for Pathogen Detection

Molecular pathogen detection has never been simpler, faster or more flexible. GENE-UP offers:

  • An easy-to-use workflow
  • A wide range of throughput levels
  • An intuitive interface
  • An open platform for maximum flexibility
  • The peace of mind that comes from making confident decisions

GENE-UP® Overview

In today’s ever-evolving food marketplace, nothing is more important than product safety. To protect your customers, your company and your reputation, you need a fast and simple method of detecting pathogens.

With GENE-UP, you’re not just getting an intuitive, real-time PCR solution for pathogen detection, you’re getting 50 years of microbiology leadership from a vigilant team that embraces the highest standards in microbiology safety. What’s more, our dedicated Customer Support and Scientific Affairs teams will work closely with you, ensuring that you can easily take full advantage of the GENE-UP system.

GENE-UP® Workflow


How GENE-UP® Works

Step 1: Sample Preparation and Enrichment

  • Standardized protocol and workflow
  • Single enrichment
  • Incubation time between 8-24 hours

Step 2: Simplified Lysis

  • Optimized productivity with Magic Cap
  • 5-minute mechanical lysis

Step 3: Amplification and Detection

  • Same PCR run for all parameters
  • Accurate results within one hour
  • Higher level of specificity
  • Real-time PCR analysis coupled with end-point melt peak analysis

GENE-UP® Benefits

FRET technology & Melt analysis

  • Increase profitability by reducing product waste
  • Decide with confidence by lessening the number of questionable results
  • Unrivaled specificity

Rapid results

  • Speed up your decision process
  • Improve your manufacturing efficiency
  • Decrease your storage cost
  • Increase sales profit

Ease of use

UNIQUE & PATENTED lysis reagent

5 minute generic lysis step

  • Improve Productivity
  • Facilitate lab workflow
  • Manage pick of activities
  • Decrease cross contamination risk
  • No need to work in batches (i.e. Gram + & Gram – follow the same lysis step)

Limited training required


Remote routine software

  • Speed-up your decision process

Generic Lysis step

  • Facilitate lab organization & workflow

Room temperature storage

Open Platform

  • Answer to your alternative testing needs (including foodborne viruses)

GENE-UP® Features

Simple to use

  • DNA extraction in 5 minutes with generic lysis step
  • Patented “Magic Cap” eliminates capping and de-capping, improving productivity
  • Room temperature storage of reagents
  • Standardized workflow and protocols

Superior performance

  • Rapid and reliable results
  • High specificity thanks to the primers and probes of FRET technology and melt analysis
  • Internal controls in every test
  • AOAC RI validated for Salmonella and E. coli O157:H7
  • AOAC RI for Listeria spp. and Listeria monocytogenes in progress

Maximum flexibility

  • Compatible lysis and PCR for all parameters
  • Anywhere, anytime reporting with remote, web-based software
  • Opportunity to design and run homebrew PCR tests
  • Capability to run CeeramTools foodborne viruses extended offer

GENE-UP® Specs

The GENE-UP® instrument can be positioned on any stable and non-moving bench. A typical installation requires workspace of: width 40” and a bench depth 24” and a clearance height of 36”.

GENE-UP® Instrument
Height (inches) 15.75
Width (inches) 9.84
Depth (inches) 20.87
Weight (lbs.) 37.42
Electrical Requirements
Power 6.5 amps @ 120 VAC
Heat Dissipated 2218 BTU/hr
Voltage 120 Volts
Electrical Consumption 20 amps
Frequency 60 Hz
Environmental Conditions
Temperature Range 59°F to 86°F with no wide temperature fluctuations
Room Relative Humidity 10% to 8-% RH, non-condensing
Altitude -328 to 9842 feet above sea level


Computer 1.7 amps @120 VAC
Monitor 0.3 amps @120 VAC
Printer 5.0 amps @120 VAC


GENE-UP® Reagents

GENE-UP offers ready-to-use test kits for your most pressing food safety concerns. The simple workflow is the same with each test, minimizing training and improving efficiencies. Current test kits include:

  • Salmonella
  • E. coli O157:H7
  • Listeria spp.
  • Listeria monocytogenes
  • More kits will be available in the future

The Salmonella and E. coli O157:H7 assays have received AOAC Performance Tested MethodsSM certification from the AOAC Research Institute (AOAC-RI):

  • Salmonella Certificate No. 061504
  • E. coli O157:H7 Certificate No. 061505

In addition to our test kits, GENE-UP has the flexibility to perform ceeramTOOLS™ kits for virus & parasite detection and simplex tests.

  • Norovirus GI
  • Norovirus GII
  • Hepatitis A
  • Hepatitis E
  • Mengovirus

ceeramTOOLS for GENE-UP®

In addition to our test kits, GENE-UP® has the flexibility to perform ceeramTOOLS kits for virus and parasite detection and simplex tests.

Food and Environmental Samples

List of Available ceeramTOOLS Detection Kits

Reference Description Number of Reactions
KNVGI ceeramTOOLS Norovirus GI Detection Kit 48
KNVGII ceeramTOOLS Norovirus GII Detection Kit 48
KNVGIGII ceeramTOOLS Norovirus GI & GII Detection Kit 48
KHAV ceeramTOOLS Hepatitis A virus Detection Kit 48
KHEV ceeramTOOLS Hepatitis E virus Detection Kit 48
KRV ceeramTOOLS Rotavirus Detection Kit 48
KADV ceeramTOOLS Adenovirus 40/41 Detection Kit 48
KMG ceeramTOOLS Mengovirus Process Control Kit 50 samples

ceeramTOOLS Norovirus and Hepatitis A Virus RT-PCR real time kits comply with ISO/TS 15216-1 and 2

The University of Barcelona's Agency of Valorisation and Commercialisation of Research Results (AVCRI) granted two exclusive license agreements with CEERAM:

  • Method for detecting HAV using real-tim RT-PCR
  • Analytical method that includes Megovirus as a control of the process
  • List of Available ceeramTOOLS Quantification Standards
Reference Description Volumes
KQNVGI ceeramTOOLS Norovirus GI Standard Kit 150 uL
KQNVGII ceeramTOOLS Norovirus GII Standard Kit 150 uL
KQHAV ceeramTOOLS Hepatitis A Standard Kit 150 uL
KQHEV ceeramTOOLS Hepatitis E Standard Kit 150 uL
KQRV ceeramTOOLS Rotavirus Standard Kit 150 uL
KQADV ceeramTOOLS Adenovirus Standard Kit 150 uL

Other ceeramTOOLS Detection & Quantification Standards

(Not yet available.  Please contact bioMérieux for more information.)

Reference Description Number of Reactions
KASV ceeramTOOLS Astrovirus Detection Kit 48
KENV ceeramTOOLS Enterovirus Detection Kit 48
KSAV ceeramTOOLS Sapovirus Detection Kit 48
KGIAR ceeramTOOLS Giardia Detection Kit 48
KCRYPT ceeramTOOLS Crytosporidium Detection Kit



Reference Description Volumes
KQASV ceeramTOOLS Astrovirus Standard Kit (Quantification) 150 uL
KQENV ceeramTOOLS Enterovirus Standard Kit (Quantification) 150 uL

The kits are ready-to-use, contain all the necessary reagents (internal control and external positive and negative controls included), have a 12 month shelf life and barcodes for traceability.

The samples for foodborne virus testing usually split between the following categories:

  • Fruits: berries, cherries, pomegranite seeds, fruit preparations
  • Produce: spinach, blanched leaf vegetables, read to eat food vegetables
  • Environmental samples: sewage water, process water, irrigation water, drinking water, surfaces...
  • Herbs and spices
  • Shellfish
  • Processed foods
  • Beverages
  • Meat
  • Dairy

GENE-UP® Software

The GENE-UP solution is commercialized with two different software options:

  • Routine: to use GENE-UP tests for the detection of the pathogens of interest (Salmonella, E. coli O157:H7, Listeria spp., Listeria monocytogenes)
  • Open: to run the CeeramTools virus kits, to create your own tests and determine your own interpretation.

GENE-UP routine software

The GENE-UP routine software is used to:

  • set up the plate map
  • check the results


GENE-UP® routine software home page


The GENE-UP routine software has been designed to be accessible from any PC in the lab AND in the office!

  • You do not need to be at the bench to setup your plate map and to check your results
  • It can speed up your decision process

To give maximum flexibility, the GENE-UP routine software can be installed on your own PC! The software can be connected to your LIMS.



GENE-UP® routine software plate map set up page


GENE-UP® routine software results page

Pioneering diagnostics