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VITEK® MS: Product Safety
Routine is Now Extraordinary
Mass spectrometry (MS) is an analytical technique for determining the elemental composition of a sample. The MS principle consists of ionizing chemical compounds to generate charged molecules and to measure their mass-to-charge ratio.
ABOUT VITEK® MS
VITEK® MS for Pharmaceutical Industry:
VITEK® MS provides ultra- rapid results:
Directly deposit the microorganism on the target slide, add the ready-to-use matrix solution and insert slide into the VITEK® MS system. Identification results are displayed within minutes.
VITEK MS offers security and traceability:
Not only is VITEK® MS 21 CFR Part 11 Compliant, but the VITEK® MS includes the VITEK® MS Prep Station, which securely links specimen information with each spot on the target slide. Unique barcodes on the plated media and the VITEK® MS target slides offer complete workflow traceability.
VITEK® MS provides accurate identification:
The VITEK® MS database, which contains a large number of specific microorganisms for the pharmaceutical industry, was developed from multiple regions, countries, sources and environments. In addition, our proprietary algorithm vastly increases the accuracy of identification.
VITEK® MS is flexible:
VITEK® MS can be integrated into quality control laboratories with either centralized or decentralized workflows by utilizing its unique VITEK® MS Prep Station. This flexibility allows multiple users to work in parallel by preparing their own target slides with the capability to identify up to 192 isolates per run.
ABOUT MASS SPECTROMETRY
Mass spectrometry (MS) is an analytical technique for determining the elemental composition of a sample. The MS principle consists of ionizing chemical compounds to generate charged molecules and to measure their mass-to-charge ratio. Such molecular “signatures” can be used for rapid bacterial identification (ID) from isolated colonies. The use of mass spectrometry for bacterial ID is especially suitable and cost-efficient for laboratories with high volumes of samples.
MALDI-TOF technology (Matrix Assisted Laser Desorption Ionization Time-of-Flight) used by VITEK® MS examines the patterns of proteins detected directly from intact bacteria. The sample to be analyzed is mixed with another compound, called a matrix. The mixture is applied to a metal plate and irradiated with a laser. The matrix absorbs the laser light and vaporizes, along with the sample, in the process gaining an electrical charge (ionization). Electric fields then guide the ions into the time of flight mass spectrometer, which separates them according to their mass to charge (m/z) ratio, and ultimately the quantity of each ion is measured. Detection is achieved at the end of the flight tube.
MALDI-TOF IN THE NEWS
CAP Today: Triple Play in Lab's MALDI-TOF Efforts
College of American Pathologists, January 2013
MALDI-TOF MS: Mass Spectrometry’s Potential for Personalized Medicine, by Nedal Safwat Ph.D.
Clinical Lab Products (CLP), April 2012
MALDI-TOF MS and the Future of Rapid Testing: Five Questions for Dr. Nedal Safwat of bioMerieux
medGadget, October 12, 2011
Mass Spectrometry: Faster Identification of Microorganisms Points to More Effective Therapies and Good Stewardship of Antibiotics
APUA Newsletter, September 7, 2011