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Delivering Confidence in Quantitative Microbiology
BIOBALL is a small water-soluble ball containing a precise number of microorganisms delivering unprecedented accuracy for quantitative microbiological quality control. BIOBALL is easy to use and requires no preparation or pre-incubation and is an accredited reference material under ISO Guide 34 standards.
BIOBALL is a small water-soluble ball containing a precise number of microorganisms delivering unprecedented accuracy for quantitative microbiological quality control. BIOBALL is easy to use and requires no preparation or pre-incubation and is an accredited reference material under ISO Guide 34 standards.
Applications include:
BIOBALL is available at four standard levels:
BIOBALL is an accredited reference material under ISO Guide 34 standard.
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BIOBALL is an ideal quantitative control for the food industry.
BIOBALL needs no preparation prior to use and is water soluble. It can be taken directly from the freezer and added to a media plate, enrichment broth or food sample.
Food pathogens can be fatal at very low levels and food test methods need to detect pathogens at very low levels. BIOBALL SINGLESHOT is a perfect inoculant for the positive control in pathogen testing. BIOBALL can be added directly to enrichment broth or it can be added as a matrix spike to a sample of sterile matrix and enrichment broth (typically 25 g of sterile matrix and 225 ml of enrichment broth).
Non-pathogen food contaminants such as yeast, mold and some bacteria, if present, are likely to be in large numbers. BIOBALL HIGHDOSE -10K is an ideal inoculant for the positive control in non-pathogen food testing. BIOBALL HIGHDOSE - 10K can be added as a matrix spike directly to a sample of sterile matrix and diluent (typically 10 g of sterile matrix and 90 mL of diluent) or it can be added directly to diluent (typically 100 mL).
The pharmaceutical industry is required to perform QC with controls in the range of 10 to 100 cfu for growth promotion and sterility testing. BIOBALL has three products that are ideal for these QC applications:
1. BIOBALL MULTISHOT - 550 used with BIOBALL Re-Hydration Fluid
Designed to provide 10 precise inoculations over an 8 hour period.
2. BIOBALL MULTISHOT - 550 used with BIOBALL 14 Day Re-Hydration Fluid
Designed for convenience and greater efficency where lower numbers of quantitative tests are performed daily.
3. BIOBALL SINGLESHOT
Designed for a single inoculation with unprecedented precision.
Sterility testing is a critical requirement in the manufacture of sterile pharmaceuticals and medical devices. Sterility testing media must undergo growth promotion testing using prescribed microbial strains and sterility testing methods must be validated to assure their capacity to recover compendia! strains when present in very low numbers. Alternative or rapid microbiological methods also require validation to verify equivalency with traditional sterility testing methods. For these purposes, use of very reliable and consistent inocula is essential to eliminate variation attributable to factors other than the performance of the media, processes or systems being tested. BIOBALL® SINGLESHOT and MulitShot - 550 strains deliver the exceptional accuracy and precision required for growth promotion testing and validation studies.
Pharmaceutical and cosmetic preparations often require antimicrobial activity to prevent microbial proliferation or to limit the effects of contamination. Preparing consistent inocula for these tests can be laborious and is often unreliable, necessitating time consuming repeat assays.
BIOBALL® MULTISHOT - 10E8 is ideal for this application and simplifies preparation and provides a precise inoculum.
Designed to provide 10 precise inoculations over a 2 hour period
BIOBALL advantages over controls prepared by serial dilution:
BIOBALL advantages over other multi dose products:
bioMérieux, Inc. can manufacture custom BIOBALL® products to suit your specific needs. We currently offer two services:
BIOBALL PLANT ISOLATE is a service offering allowing you to order BIOBALL with the strain that you require. BIOBALL PLANT ISOLATE maintains the high level of quality you are accustomed to with standard BIOBALL products.
Any strains from your in-house collection can be used to manufacture a BIOBALL PLANT ISOLATE, whether they're environmental monitoring isolates, contaminants of products or raw materials or from any other source within your facility.
| Single Dose (60) | Multi Dose (550) | Multi Dose (10E8) | |
| Mean cfu | 60 ± 20% | 450 - 650 | 5 x 107 to 1.4 x 108 |
| Coefficient of variation (CV) | <= 20% | <=20% | <=20% |
| Minimum number of vials per strain | 100 vials (100 tests) | 100 vials (1,000 tests) |
100 vials (1,000 tests) |
| Expiration from date of manufacture | 12 Months | 12 Months | 12 Months |
| Rehydrated stability | N/A | Two hours if used with standard BIOBALL rehydration fluid | Two hours if used with standard BIOBALL rehydration fluid |
A BIOBALL PLANT ISOLATE will take approximately 12 weeks from the strain arriving at our facility, for development, manufacturing, stability testing and shipment back to you in BIOBALL format. We will provide an estimated delivery date once the order is placed.
bioMérieux, Inc. can manufacture BIOBALL with any strain selected from specified culture collections and at any CFU level required. BIOBALL SELECT can also be made using any of your in-house strains or any proprietary strain with commercial or analytical value.
A BIOBALL PLANT ISOLATE will take approximately 12 weeks from the strain arriving at our facility, for development, manufacturing, stability testing and shipment back to you in BIOBALL format. We will provide an estimated delivery date once the order is placed.
BIOBALL CUSTOM SERVICES is dedicated to providing your BIOBALL SELECT or PLANT ISOLATE order at the exceptional levels of precision and quality associated with the BIOBALL brand. We are dedicated to delivering superlative customer service, continually seeking to improve our service to you, and evolving our business to meet your changing needs. BIOBALL CUSTOM SERVICES takes pride in providing exceptional customer service and product performance.
When it comes to food safety, you can never be too accurate.
BIOBALL LUMINATE® is a small, water-soluble ball containing a precise number of microorganisms, with a much higher recovery rate and lower standard deviation compared to serial dilution. Each BIOBALL LUMINATE microorganism is tagged with a Green Fluorescent Protein {GFP) marker, making it easy to distinguish from external contaminants-whether using traditional or rapid testing methods.
High fluorescence helps unlock value in the laboratory:
BIOBALL LUMINATE is intended to be used as a daily control QC reference material for traditional and rapid method pathogen testing for food safety testing laboratories.